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10.1016/j.jlr.2021.100088

Chen et al., Synthesis of CaCO 3 -based nanomedicine for enhanced sonodynamic therapy via amplification of tumor oxidative stress

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Additional prominent proteomic signatures included the upregulation of enzymes involved in glucose metabolism (ALDO-1, GPD-3, ENOL-1, PYC-1, LDH-1, MDH-2), mitochondrial stress (GST-4, HSP-6), ubiquinone synthesis (CLK-1) and intermediates of the tricarboxylic acid cycle (SDHD-1, SDHA-1, ACO-2, MMAA-1), whereas fatty acid desaturase FAT-7 was significantly downregulated (Fig

How things go bad As we get older, our brain chemistry and energy metabolism changes.[vii] Nerve growth factor in the brain declines Acetyl-L-Carnitine levels decline Acetylcholine levels decline Mitochondria loses efficiency All of these age-related changes are contributing factors to cognitive impairment and the neurodegenerative diseases of aging, including Alzheimers and dementia
