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Hence, elevated cholesterol levels during aging could be a risk factor for A toxicity in AD because amyloid concentration on lipid and protein platforms leads to peptide aggregation into the most toxic -sheet-rich forms (Matsuzaki and Horikiri, 1999

Except for heart failure, for which SS-31 has shown mixed or inconclusive results, the peptide has had varying degrees of success in animal models

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doi: 10.1089/ars.2007.9.169 248 WhiteheadG.ReganP.WhitcombD

Moreover, some authors suggest performing crural relaxing incisions to achieve a tension-free crural closure [30]