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The characteristic features of MSA include both motor and autonomic disturbances including Parkinsonism, cerebellar ataxia, orthostatic hypotension, urinary dysfunction and cardiovascular issues which often has fatal consequences ( Most of the PD cases are linked to late adult onset and are sporadic in nature
Given the short half-life, twice-daily dosing provides additional exposure compared to once-daily protocols at the same total dose

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(2) Hillary H Le, Suleyman S Cinaroglu, Elise C Manalo, Aysegul Ors, et al (2021) Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells eBioMedicine, 2021 Oct 21, Volume 73, Page 103646
