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Transcriptome analysis of post-mortem samples from the lateral temporal lobe of AD patients shows increased expression of genes associated with chromatin remodeling (genes encoding histone acetyltransferases CBP (CREBBP), p300 (EP300) and TRRAP (a subunit of the SAGA/ATAC complex), histone deacetylases SIRT1 and HDAC4, histone methyltransferases (CXXC31), and histone demethylases (JMJD6))

Across a full treatment protocol, consistent small errors compound

Liu H, Tian Y, Bao X, Li Y

The Fuze looks and feels more substantial

Neuronal autophagy and neurodevelopmental disorders

Histone deacetylase inhibitors (HDACi)s have gained attention for their ability to modulate protein transcription, and in the context of G6PD, have been shown to increase PPP flux by upregulating and downregulating G6PD expression in cancer cells [78,79]