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Finally, we will include an overview and an assessment of the pros and cons of the approaches used to measure the glycocalyx and assess its function ex vivo, including electron (287) and confocal microscopy (24), as well as alternative approaches using state of the art atomic force microscopy (275) and clinical approaches to measure the glycocalyx in vivo (212, 250)

Interestingly, both in vivo and in vitro studies have shown that the accumulation of -syn in the mitochondria of human DA neurons leads to decreased complex I activity, increased production of ROS, reduced substrate-specific respiration, and increased mitophagy [86, 87]

Arozarena, I

Whitby PW, VanWagoner TM, Springer JM, Morton DJ, Seale TW, Stull TL

The injections usually also contain a local anaesthetic that provides immediate pain relief lasting a few hours

This highlights an important distinction between biological plausibility and clinical evidence