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The implantation process consists of three stages: apposition, adhesion, and invasion

In CHD, acute coronary syndrome (ACS), and ischemic cardiomyopathy, HDL have reduced ability to inhibit oxidation of LDL, likely through reduced PON1 levels as reported in CHD (845,863,864)

Namazi, N., et al

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Although it could be theoretically possible to enhance the reverse cholesterol effects of LXRs without targeting hepatic lipogenesis with the use of LXR-specific ligands since most of the hepatic responses are due to activation of LXR, this will be a difficult challenge as the ligand binding pocket in both isoforms has been shown to be nearly identical