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Evidence Summary Consistent animal study results but no human data 2 Human 14 Animal 4 In Vitro 3 Reviews 23 Total This content is for educational purposes only and is not medical advice

On the central mechanism underlying ghrelin's chronic pro-obesity effects in rats new insights from studies exploiting a potent ghrelin receptor antagonist

PMID: 11713213 Stier, H., et al

Never shake vigorously, as this can damage the peptide structure

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The most important factor is consistency of timing and route day to day, since the mechanism works cumulatively rather than as an acute event to time around a meal