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The pharmacological properties of this herb are primarily ascribed to a diverse range of bioactive constituents, which include phenylpropanoids (such as rosavin, rosarin, and rosin), salidroside, tyrosol, flavonoids, tannins, and essential oils ( 5.2 Mechanisms of action The antidepressant properties of Rhodiola rosea are characterized by a multi-faceted mechanism of action, indicative of its extensive phytochemical composition (Figure 1)

In 2014, LaRocca et al

Note the need for TCA recycling of GABA within astrocytes