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Reduced consumption of NADPH has been observed when fatty acid synthesis is inhibited by AMP-activated protein kinase (AMPK) via inhibition of acetyl-coenzyme A carboxylase (55)

A deproteinization study

These authors also showed that Actinobacillus pleuropneumonia, a bacterium lacking the NadV gene, transformed with murine PBEF acquires NAD independence, confirming that the enzymatic activity is evolutionarily conserved from bacteria to mammals (98)

However, the Tpx1 reduction/recycling kinetics are also extremely fast, while OxyR reduction is not, at least once expressed in fission yeast