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Reproduction 153(5):683694 Funding The authors did not receive support from any organization for the submitted work

Top contributors to the PLS-DA included nucleotides and their amino acid and PPP sugar precursors

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Clinical, Cosmetic and Investigational Dermatology 2014:7 submit your manuscript | www.dovepress.com Dovepress Dovepress 272 Watanabe et al Table 3 Benecial effects of GSSG treatment of skin, as scored by investigator and subjects Week 0 2 4 6 8 10 Group Placebo GSSG Placebo GSSG Placebo GSSG Placebo GSSG Placebo GSSG Placebo GSSG N 30 30 30 30 30 30 30 30 30 30 30 30 Investigator Skin whitening Score 0 100.0 100.0 100.0 100.0 100.0 76.7 90.0 13.3 46.7 3.3 33.3 0.0 Score 1 0.0 0.0 0.0 0.0 0.0 23.3 10.0 73.3 53.3 60.0 63.3 33.3 Score 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.3 0.0 36.7 3.3 66.7 Wrinkle reduction Score 0 100.0 100.0 96.7 100.0 100.0 83.3 100.0 76.7 96.7 40.0 76.7 10.0 Score 1 0.0 0.0 3.3 0.0 0.0 13.3 0.0 13.3 3.3 40.0 23.3 56.7 Score 2 0.0 0.0 0.0 0.0 0.0 3.3 0.0 10.0 0.0 20.0 0.0 33.3 Subjects Skin whitening Score 0 100.0 100.0 100.0 100.0 100.0 76.7 90.0 13.3 46.7 3.3 16.7 0.0 Score 1 0.0 0.0 0.0 0.0 0.0 23.3 10.0 73.3 53.3 63.3 60.0 23.3 Score 2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.3 0.0 33.3 23.3 76.7 Wrinkle reduction Score 0 100.0 100.0 100.0 100.0 100.0 83.3 100.0 80.0 96.7 46.7 63.3 16.7 Score 1 0.0 0.0 0.0 0.0 0.0 13.3 0.0 10.0 3.3 33.3 36.7 53.3 Score 2 0.0 0.0 0.0 0.0 0.0 3.3 0.0 10.0 0.0 20.0 0.0 30.0 Note: Data are expressed as percentages of the total number of subjects