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The rest period between CS exposures was typically overnight, generally about 16 hours

By contrast, in the experiments in which the course of ischemia was not reversed, decreased NO levels in the colon tissue appeared as an immediate heavy loss of endothelial cells from the vascular wall, which resulted in a lower eNOS production ability[42]

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Thus, bioavailability will be 100% directly after injection, as the active substance is administered directly into the blood