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The PER1/HIF-1alpha negative feedback loop promotes ferroptosis and inhibits tumor progression in oral squamous cell carcinoma

doi: 10.1007/s00266-025-05077-3

Sci Rep 10(1):13660

Mitochondrial dysfunction in ME/CFS Mitochondrial dysfunction is implicated as a key pathogenic process in ME/CFS, underpinned by mechanisms involving oxidative and nitrosative stress, immune-inflammatory pathways, and metabolic disturbances

The pivotal role of cysteine (the reduced form of cystine) as the rate-limiting substrate for GSH synthesis becomes evident here

Hydrolyzed Collagen and Squalane help improve the skin's smooth feel while supporting moisture retention, making rough areas such as elbows, knees, and legs feel softer