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A., El-Remessy, A
On the other hand, internalization by deltorphin analogues is associated with partial recycling and resensitization of DOR signalling [88], both of which may contribute to a faster recovery of analgesic efficacy upon repeated administration of this type of ligands [86]
However, it is also possible to measure the GSSG concentration of the sample by first treating the sample with 4-vinylpyridine (4-VP) to sequester GSH
It represents an off-label approach based on individual experimentation
This excellent safety profile doesn't eliminate the need for medical oversight
