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Based on characteristic serological markers of HT, a prospective clinical trial demonstrated that Se supplementation reduced TPO-Ab titers and improved the quality of life of patients (45), which is consistent with the results of several intervention studies or meta-analyses (5155)

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Chalco-naringenin, phlorizin, arbutin, and phloretin are the major examples of chalcones

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Michailidou Z (2019) Fundamental roles for hypoxia signalling in adipose tissue metabolism and inflammation in obesity

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Briefly, 2 days post-confluent 3T3-L1 preadipocytes incubated with DMEM containing 10% FBS, 1 M dexamethasone (Sigma-Aldrich), 0.5 mM 1-methyl-3-isobutylxanthine (Sigma-Aldrich) and 5 g/mL insulin (Sigma-Aldrich)

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