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This fatty-acid-potentiated GSIS was suggested to be mediated through the formation of long-chain acyl-CoAs [56]

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Finally, a modeling approach in 86 patients with varying degrees of hepatic steatosis pointed out a causative involvement of reduced de novo glutathione synthesis in NAFLD, which was in part overcome after supplementation of glutathione precursors [32]
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In some cases the phenotype is linked to mislocalization of the pigments to the cytoplasm 29 or vesicle-like structures 19,30

10.1073/pnas.0510197103 96 DharmadasaT.KiernanM