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This dimerization appears to induce a switch in intracellular signaling cascades in which administration of a dopamine agonist (quinpirole) alone leads to a rapid increase in Ca 2+ levels, an effect not observed in preparations expressing D2R in the absence of GHSR1a (Kern et al., 2012)

Still, based on the results, a migraine doctor might expect an average of 7 to 9 less headache days per month with their patient after 24 weeks on Botox (or 2 treatments)