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When circadian rhythms are normalized and cellular stress is reduced, the brain becomes more responsive to interventions targeting neurotransmitters and neuroplasticity

Holm-Bentzen M, Jacobsen F, Nerstrm B et al: A prospective double-blind clinically controlled multicenter trial of sodium pentosanpolysulfate in the treatment of interstitial cystitis and related painful bladder disease

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They bind to specific receptors on the surface of cells, triggering a cascade of cellular responses

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