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Our collaborative work demonstrated that severe reactive astrocytes release excessive amounts of the inhibitory gliotransmitter GABA via bestrophin 1 (BEST1) channels, contributing to memory deficits and impairing synaptic plasticity 58,59

General safety observations from published health sources show: Oral glutathione is well tolerated in moderate doses Long-term use does not suppress natural production No evidence suggests dependency or rebound effects Side effects are rare and usually mild Mild side effects, when they occur, may include bloating or headache, often linked to excessive dosing rather than duration of use

The second reaction is catalyzed by glutathione synthetase to condense -GC with glycine to produce GSH [65]

This may be somewhat surprising given strict vegans and vegetarians only account for roughly 3% of global consumers

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