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Long-chain fatty acids (LCFAs) cannot directly cross the mitochondrial membrane because of their high polarity and are activated to long-chain acyl-CoA by acyl-CoA synthetase (ACS)

2016 PMC4718868 Conrad, E

& Sampson, E

Specifically, as an endogenous ligand of the aromatic hydrocarbon receptor, trans-3-indoleacrylic acid upregulates the expression of aldehyde dehydrogenase 1 family member A3, leading to increased production of NADH by utilizing retinol as a substrate

The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration