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These animal studies suggest that vitamin C supplementation may reduce and possibly prevent opioid drug tolerance, drug craving, and physical dependence

This is an area where ergothioneine may have a practical edge over vitamin C specifically: its tolerability profile is excellent

B.PawlowskiM.MeyerZ

Detailed review of MUNIX, TMS, and other advanced neurophysiologic studies, such as peripheral threshold tracking nerve conduction studies to measure spinal motor neuron excitability, are reviewed elsewhere [74,75,76,77]

doi: 10.1210/jc.2012-2244

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