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Interestingly, Tau is abundant in ECs and aids in their protection against oxidative stress, inflammation, and cell apoptosis suppression (209, 210)

Agarwal S, Vyas P, Nirwan N, Vohora D

Proc Natl Acad Sci USA 96, 46864691 (1999)

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Malformations of cortical development: molecular pathogenesis and experimental strategies

In CKD, uremic toxins (e.g., indoxyl sulfate) synergize with iron overload to suppress GPX4, further enhancing ROS-mediated eryptosis ( 4 The role of eryptosis in patients 4.1 The role of eryptosis in non-dialysis-dependent patients Eryptosis, the programmed death of erythrocytes characterized by PS exposure on the cell membrane, has emerged as a critical contributor to renal anemia in non-dialysis-dependent chronic kidney disease (NDD-CKD), with estimated glomerular filtration rate (eGFR) identified as its key determinant ( r 2 = 0.22) and the NDD-CKD subgroup ( r 2 = 0.10)