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APOE comes in four variants: APOE1 (extremely rare and not considered further), APOE2 (rare), APOE3 (most common), and APOE4 (common) ( APOE4 is evolutionarily the oldest ( APOE variant one carries affects tau and alpha-synuclein levels (Huynh et al., 2017

New York, NY: Elsevier Science Publishing

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Additionally they do not need SUOX SNPs to have this happen (they may have it, but it isnt necessary)

and 5 was defined as normal functioning of tail motor control
