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3 Emerging research suggests GLP-1 medications may be particularly effective for menopause weight gain: A 2025 study presented at the Menopause Society meeting found that postmenopausal women on hormone replacement therapy (HRT) lost 19.9 percent of their body weight on tirzepatidesignificantly more than the 15.6 percent loss seen in postmenopausal women not using HT

The most important thing you can do is work with a physician who evaluates your full medical picture before prescribing

Stopping GLP-1 therapy typically results in reversal of therapeutic effects, including deterioration in blood glucose control and weight regain within weeks to months

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RELATED: GLP-1 agonists: Uses, common brands, and safety info When it comes to the best weight loss medication for PCOS, a 2023 article published in the journal American Family Physician points to Metformin as a first-line treatment for individuals with PCOS who have metabolic issues such as insulin resistance