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Description
-AR desensitization/down-regulation diminishes adrenergic signaling and cardiac contractile reserve, and is conventionally considered to be detrimental in HF progression
It often appears during dose escalation phases and resolves within days
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
doi: 10.1021/acschemneuro.8b00276 [DOI] [PubMed] [Google Scholar] 153.Zhou ZD, Xie SP, Saw WT, Ho PGH, Wang H, Lei Z, et al
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