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Most evidence comes from rodent studies and user reports , not large clinical trials

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

Diffusion tensor MR imaging in spinal cord injury

Challenges in Developing QSIs, Including Specificity and Potential Resistance A significant challenge in the development of QSI arises from the gradual evolution of resistance to QSI in bacteria [208]

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According to NICE Clinical Knowledge Summaries and the British National Formulary (BNF), the recommended treatment regimens are: For patients without neurological involvement : Initial treatment: hydroxocobalamin 1 mg intramuscularly three times a week for 2 weeks Maintenance: hydroxocobalamin 1 mg intramuscularly every 3 months for life For patients with neurological involvement : Initial treatment: hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement Maintenance: hydroxocobalamin 1 mg intramuscularly every 2 months for life If neurological symptoms are present, treatment should be started urgently to prevent irreversible damage