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The AGE-RAGE system may be responsible for the failure of ovulation characteristic of PCOS: in a model of human cell lines of granulosa, observed that the AGE interfere in vitro with the action of LH leading to altered follicular development and therefore the dysfunction ovulatory associated with PCOS [65]

Dallman, 1989

vitaminas C, A, D, E, K, B 1 , B 2 , B 3 , B 6 y B 12

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Although pharmacological stimulation of the hypothalamicpituitarygonadal axis using agents such as human chorionic gonadotropin and selective oestrogen-receptor modulators may promote recovery, these interventions require specialised medical supervision