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Diminished levels of glutathione have always been associated with aging
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Not enough research has been done to say whether SAM-e can treat depression, arthritis, or liver disease
Front Pharmacol 11:999 Zadroniak M, Szymaski M, uszczki JJ (2023) N-Acetyl-L-cysteine affects ototoxicity evoked by amikacin and furosemide either alone or in combination in a mouse model of hearing threshold decrease
Current therapeutic approaches aim to modulate these pathways, including direct Nrf2 activation and glial-targeted interventions, although significant challenges persist in delivering antioxidant agents across the BBB and in validating neuroprotection markers
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