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Overall, the evidence supports the use of B12, on its own or in addition to other supplements, for the reduction of homocysteine levels

Additional engineering strategies include the expression of dominant-negative TGF- receptors to resist TME-mediated suppression, or the integration of nutrient transporters such as GLUT1 into CAR constructs to improve metabolic adaptability and glucose uptake in nutrient-deprived environments [253,254,255]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Anastasiou I.A., Tentolouris A., Sarantis P., Katsaouni A., Rebelos E., Mourouzis I., Pantos C., Tentolouris N

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