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10.1002/ieam.4558 43 StrbeS.GojkovicS.KrezicI.ZizekH.VranesH.BarisicI.et al (2021)

Women get wider, men become more narrow What compounds the issue of orgasmic response during intercourse is the fact womens vaginas get wider over time from a combination of aging and childbirth, but mens penises start getting smaller as they mature

Protects Skin from Aging and UV Damage Ergothioneine builds up in skin cells through the OCTN-1 transporter and helps counter several key drivers of skin aging: Sun damage: Absorbs UV light and helps prevent UV-triggered DNA damage [14] Collagen loss: Inhibits MMP-1, the enzyme that breaks down collagen [15] Uneven tone: Clinical data show reduced wrinkles, age spots, and hyperpigmentation by suppressing excess melanin [15] Loss of firmness: Protects collagen and elastin and supports better hydration and elasticity [15] Inflammation: Its anti-inflammatory properties help calm acne, rosacea, psoriasis, and atopic dermatitis, and in some models it outperforms coenzyme Q10 and vitamin C against free radicals [15] These benefits have been observed with both topical ergothioneine and oral supplementation

The COX-2 and 5-LOX pathways were used for anti-inflammatory potential of compounds

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About 30% of human genes are regulated by micro-RNA classes of small RNA [95]