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When compared to an untreated control, a combination of two herbicide safeners improved the GSH pool and its precursors, Cys and -ECS

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Preclinical studies have shown that several dual IGF-1R/IR RTKi, including OSI-906 (linsitinib) [159], BMS-554417 [148], and BMS-754807 [160,161], exhibit anti-proliferative and pro-apoptotic affects in breast tumor cells, and inhibit breast tumor growth in vivo when given alone or in combination with hormone therapy

Banerjee A, Zhang X, Manda KR, Banks WA, Ercal N

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J Immunol 143:197481, PMID: 2789253 Markovic J, Borrs C, Ortega A, Sastre J, Via J, Pallard FV (2007) Glutathione is recruited into the nucleus in early phases of cell proliferation