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doi: 10.1073/pnas.0712401105 56 KokubunH.EbinumaK.MatobaM.TakayanagiR.YamadaY.YagoK

Stimuli-responsive nanocarriers for delivery of bone therapeutics - barriers and progresses

This hyperglycemia may also alter gene and protein expression, endothelial cell permeability, and depletion of antioxidant molecules, including Glutathione S-transferases (GSTs), which play an important role in the cellular detoxification process [37, 41, 43, 44, 45]

However, the reduction in pre-B cells during zinc deficiency mirrors the effect observed in T cells and is associated with altered glucocorticoid metabolism and increased apoptosis, highlighting shared mechanisms of immune impairment under zinc deficiency [376]