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Mechanistically, Nrf2 activation leads to transcriptional activation of antioxidant enzymes, including microsomal epoxide hydrolase, heme oxygense-1 (HO-1), NADPH: quinone oxidoreductase 1 (NQO-1), and glutamate cysteine ligase (GCL), which catalyzes the initial and rate-limiting step in GSH synthesis

Biochem Pharmacol 64: 10371048

they stabilize the mitochondrial DNA (mtDNA) or are associated with mitochondrial RNA (mtRNA) translation, oxidative stress, iron metabolism and tumour suppression [18]

Interventions: After 14 days of oral administration of 1250 mg of the melon extract/gliadin (n=9) or vehicle (n = 9), animals underwent 30 min of thoracic aortic cross-clamping and 4 h of reperfusion

While variance in plasma levels were noted, contrasting results have been seen when looking at in vivo studies