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Additionally, dietary micronutrients such as folate and vitamins B12 and B6 contribute to 1C metabolism, as shown in Figure 2

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After a follow-up period exceeding ten years, it was found that the local-regional recurrence (LRR) in the group receiving radiotherapy alone was slightly higher than those who underwent BCS followed by radiotherapy or mastectomy

The circRNAs that are found to be biomarkers of ferroptosis may provide new perspectives for the detection of ferroptosis

Therefore, MCT1 can mediate lactate uptake in oxidative cells where lactate is consumed, but under specific conditions where the intracellular lactate concentration is high, it can also mediate lactate efflux to maintain metabolic homeostasis [35, 44, 45]

Ethics declarations Funding The Natural Sciences and Engineering Research Council of Canada (CHRPJ-508393-2017), Canadian Institutes of Health Research (CPG-151963), and the Milken Institute (2021-0825) are gratefully acknowledged for funding