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Hydroxocobalamin is classified as Pregnancy Category C in the United States, indicating that risk to the fetus cannot be ruled out in the absence of definitive human data

Acute symptoms such as fatigue may improve within days, whilst neurological symptoms like paraesthesia typically require weeks to months of treatment

Vitamin B12 among vegetarians: status, assessment and supplementation
Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise

[1] This characteristic has led to the widespread belief that vitamin B12 toxicity is virtually impossible

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