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Combined Inhibition of MTAP and MAT2a Mimics Synthetic Lethality in Tumor Models via PRMT5 Inhibition

Improvements in ALT levels suggest better liver function, as lower ALT levels indicate reduced liver cell damage and inflammation [103,104]

Cardiovascular complications, including cardiomyopathy and structural cardiac remodelling, appear to represent the most clinically significant outcomes, as comprehensively described by Iliakis and Stamou (90)

NF-B is a ubiquitous nuclear transcription factor that plays an important role in inflammatory and immune responses by mediating the secretion of inflammatory cytokines, including TNF-, IL-1, and IL-6 [234]

Interestingly, in patients treated for mandibular fractures, inflammatory changes at the Ti-6A1-4V implant site were observed several months or several years after osteosynthesis, which could be due to individual characteristics and the presence of comorbidities

Rat livers were placed in Thermo-ROS solution containing 10% dimethyl sulfoxide (DMSO), and stored at -20 0 C for three days (72 hours)
