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A novel bifunctional anti-PD-L1/TGF- Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells

Yuan G, Gao W, Yang Y, Wu Y

However, IGF-1 is only used for muscle growth, and therefore, can increase cancer risk as well

Cell (2019) 177(5):126279.e25

data curation, L.A

The broad spectrum of substrates means GST activity has been implicated as a determinant of efficacy for many drugs [2,3], with isoenzyme, GST P1-1 most commonly associated with both innate and acquired drug resistance during cancer chemotherapy [1,4,5], including 5-fluorouracil- and cisplatin-resistant gastric cancers [6] and doxorubicin-resistant prostate cancer [7], because of overexpression in drug-resistant cell lines [8,9]