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All experiments were carried out in accordance with the Guide for the Care and Use of Laboratory Animals [20] and with approval from the Institutional Animal Care and Use Committee at the University of Texas Medical Branch

The increased protein binding of hydroxocobalamin sustains circulating vitamin B12 levels for longer than cyanocobalamin

Description Description For Research Use Only Not for Human or Animal Consumption 5-Amino-1MQ is a small-molecule compound studied in preclinical research as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular NAD metabolism

Hemmer B., TU Mnchen, Department of Neurology

The theoretical concern is off-target methylation interference, since NNMT isnt the only methyltransferase in one-carbon metabolism pathways