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Description
doi: 10.1161/01.hyp.0000032100.23772.98

Am J Clin Nutr 1981
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The main nutrients required for methylation are B vitamins, particularly B6, B9 (folate) and B12

Some 1,257 patients with diabetic neuropathy were randomly assigned to receive, in double-blind fashion, placebo or acetyl-L-Carnitine at a dose of 500 or 1,000 mg 3 times a day for 1 year

Within 2-4 weeks of daily supplementation you should have elevated levels of plasma L-Carnitine as well as fully saturated creatine stores
