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In a previous report, 2-week administration of pefloxacin (900 mg/kg/day) to rats caused the emergence of tenocytes with round nuclei in Achilles tendons ( Biomechanical examination Biomechanical examination of the rats was performed using a tensile testing machine (MODEL-1310VRW, Aikoh Engineering, Osaka, Japan)

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Richman SA, Nunez-Cruz S, Moghimi B, Li LZ, Gershenson ZT, Mourelatos Z, et al

Liposomal technology

2016;11(6):e0157602

Ex vivo studies have shown that increasing glucose metabolism with dichloroacetate, a pyruvate mimetic that activates PDH, increases glycolytic flux and improves LV function.87 This has been followed up in vivo , where dichloroacetate administration returned rates of glucose metabolism of diabetic rats to control levels.88 This occurred alongside reversal of impaired diastolic function and normalisation of blood glucose concentrations
