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Pepoy, B

CoQ 10 plays a role in this process as an essential cofactor of the ETC located in the inner mitochondrial membrane and serves the following functions: [1] [7] electron transport in the mitochondrial ETC, by shuttling electrons from mitochondrial complexes like nicotinamide adenine dinucleotide (NADH), ubiquinone reductase (complex I), and succinate ubiquinone reductase (complex II), the fatty acids and branched-chain amino acids oxidation (through flavin-linked dehydrogenases) to ubiquinolcytochrome-c reductase (complex III) of the ETC: [1] [7] CoQ 10 participates in fatty acid and glucose metabolism by transferring electrons generated from the reduction of fatty acids and glucose to electron acceptors

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1318 The importance of inflammation in the pathogenesis of the ocular surface disease of dry eye, termed keratoconjunctivitis sicca, is underscored by the clinical improvement seen with anti-inflammatory therapies such as cyclosporine A, corticosteroids and doxycycline
