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Of the 27 dogs: 22% had an elevated MMA value, indicative of vitamin B12 depletion at the tissue level

Acid sphingomyelinase (ASMase) is indirectly activated in this way and its activation correlates with its translocation from intracellular stores onto the extracellular leaflet of the cell membrane [11]

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Additionally, disruption of ion channels such as VDAC1 and VDAC2 contributes to mitochondrial calcium overload and oxidative stress, further exacerbating cataractogenesis by impairing lens transparency and cellular homeostasis [28]