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Oxidative medicine and cellular longevity , 2020.Bardoxolone methyl displays detrimental effects on endothelial bioenergetics, suppresses endothelial ET-1 release, and increases endothelial permeability in human microvascular endothelium 211 TamagnoE.GuglielmottoM.VasciaveoV.TabatonM

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations BSO: DL-buthionine-S, R-sulfoximine carboxy-H2-DCFDA [5-(and)-6-carboxy-2: 7-dichlorodihydro-fluorescein diacetate] DEM: diethylmaleate GAPDH: glyceraldehyde-3-phosphate dehydrogenase NA: nicotinic acid NAD: nicotinamide adenine dinucleotide NaDOC: sodium deoxycholate NAM: nicotinamide PARP: poly(ADP-ribose) polymerase ROS: reactive oxygen species TEM: transmission electron microscopy References Reddy BS

Subjects started at 2mg twice weekly and gradually increased the dosage until desired results were reached

International Agency for Reserach on Cancer (IARC), 165-169, 2015

P values are represented using the GraphPad PRISM style
