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doi: 10.1210/jc.2010-2905 49 FallahiPFerrariSMRagusaFRuffilliIEliaGPaparoSRet al

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(2012) modelled a glutathione/thioredoxin system used to modulate mitochondrial H 2 O 2 emissions, and validated the model using data from heart mitochondria from mouse, rat, and guinea pig (Aon et al., 2012)

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What Are the Limitations of This Research

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Fumarate itself is a Michael acceptor, and the covalent attachment to protein cysteines corresponds to the post-translational modification known as succination [142] and fumarate has been recently demonstrated to yield a glutathione thioether in in vitro treated cells [142]

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Reduces oxidative stress Oxidative stress occurs when theres an imbalance between the production of free radicals and the bodys ability to fight them off

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however, the data reliably document that a positive band can be expected there

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