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[DOI] [PubMed] [Google Scholar] Marconi C, Sessi G, Carpinelli A, Cerretelli P
These metabolites significantly differed between septic mice with and without signs of acute kidney injury (AKI), as defined by Kidney Disease Improving Global Outcomes (KDIGO), as creatinine levels tripled the average of sham mice
A 2024 study in MASH patients and mouse models further confirmed that L-carnitine supplementation suppresses inflammatory gene expression ( Tnf, Il6, Il1b ) and downregulates pro-fibrotic genes ( Acta2, Col1a2, Tgfb1, Pdgfrb, Pdgf-b, Pdgf-c ), reducing -smooth muscle actin (-SMA) and platelet-derived growth factor receptor beta (PDGFR) protein levels (73)
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These aspects are extensively detailed in a recent review[13]
