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Meanwhile, selenium-supplementation has been demonstrated to upregulate GPX4 expression by coordinated activation of the transcription factor AP-2 gamma (TFAP2C) and specificity protein 1 (SP1), which protects against ferroptosis-related cerebral hemorrhage ( de novo synthesis of GSH

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Our separate assessment of each metabolite using optimized enzymatic assays was calibrated against validated standards and LC-MS and allows high-throughput analyses
