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Both equine and rodent models consistently show regenerative effects

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It appeared unlikely that therapeutic MeCbl would have any advantage over OHCbl in the treatment of MeCbl deficiency or cobalamin deficiency in general.25 Another cellular study showed that the lysosomal reduction to cobalamin, when B 12 is supplemented as AdCbl, was 67 times slower than the reduction of MeCbl to cobalamin

Part of this is managing expectations despite innovations, there are some situations in which returning to pre-surgery levels in a sport is not safe or realistic

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