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Similarly, TP-Por COF nanosheets loaded with IR783 and cisplatin derivatives demonstrate concurrent photothermal and chemotherapeutic activity, achieving 92% tumor growth inhibition in murine models [148]

Exogenous RONS contributors include air and water pollution, tobacco, alcohol, heavy or transition metals, drugs (e.g., cyclosporine, tacrolimus, gentamicin, and bleomycin), industrial solvents, unhealthy food (e.g., smoked meats, used oils, and fats), radiation, and bacterial, fungal, and viral infections (35, 36)

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In the ideal situation both pieces of information, from the QSAR model and from the Applicability Domain Index, should be assessed

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The D-2HG enantiomer is produced downstream of mutant isocitrate dehydrogenase enzymes in glioma and acute myelogenous leukaemia, and the L-2HG enantiomer is produced under hypoxia
