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The central role of barium may stem from its dual neurotoxic mechanisms: (i) barium exerts its effect by targeting inward rectifier potassium channels (IRCs) of the KCNJx gene family, where it binds efficiently to the selectivity filter and subsequently blocks the ion conduction pore

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Rocking from side to side helps to start the leg movement

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Once the needle placement is confirmed, the therapeutic medication is injected into the joint