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Reducing your dose and taking it with food can often help eliminate this sensation

The paf1 complex: A keystone of nuclear regulation operating at the interface of transcription and chromatin

FOXO4-DRI is a first-in-class senolytic peptide that selectively eliminates senescent "zombie cells" by disrupting the FOXO4-p53 interaction
doi: 10.1038/cddis.2014.513

[DOI] [PubMed] [Google Scholar] 100.Branzk N., Lubojemska A., Hardison S.E., Wang Q., Gutierrez M.G., Brown G.D., Papayannopoulos V

Your colon has more time to absorb water from stool, making it harder and more difficult to pass
