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Description
The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure
Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics comparison with orlistat (Xenical) Obesity (Silver Spring) 2010;18(1 ): 10815
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The Lancet
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Doses up to 1,000 mcg, though unnecessary, aren't harmful
